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Advances in sympathetic nerve recording in humans

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posted on 2024-07-09, 23:04 authored by Elisabeth LambertElisabeth Lambert, Dagmara Hering, Markus Schlaich, Gavin LambertGavin Lambert
In humans, sympathetic activity is commonly assessed by measuring the efferent traffic in the peroneal nerve. The firing activity is the sum of several active neurons, which have the tendency to fire together in a bursting manner. While the estimation of overall sympathetic nervous activity using this multiunit recording approach has advanced our understanding of sympathetic regulation in health and disease no information is gained regarding the underling mechanisms generating the bursts of sympathetic activity. The introduction of single-unit recording has been a major step forward, enabling the examination of specific sympathetic firing patterns in diverse clinical conditions. Disturbances in sympathetic nerve firing, including high firing probabilities, high firing rates or high incidence of multiple firing, or a combination of both may impact on noradrenaline release and effector response, and therefore have clinical implications with regards to the development and progression of target organ damage. Understanding the mechanisms and consequences of specific firing patterns would permit the development of therapeutic strategies targeting these nuances of sympathetic overdrive.

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ISSN

1664-042X

Journal title

Frontiers in Physiology

Volume

3 FEB

Article number

article no. 11

Publisher

Frontiers Research Foundation

Copyright statement

Copyright © 2012 Lambert, Hering, Schlaich and Lambert. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

Language

eng

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