Effect of Collagen type-I on the rate of osseointegration of Ca-containing biodegradable Mg-Zr based alloys

Mg-Zr based biodegradable implants alloyed with Ca were investigated to assess their biocompatibility and efficacy in bone formation and osseointegration. Bare alloys, containing Ca, exhibited low surface energy, poor corrosion-resistance, reduced osteoinduction and bone integration activity. Upon coating with Collagen type-I, these alloys demonstrated enhanced performance as an implant material that are suitable for rapid and efficient new bone tissue induction with optimal mineral content and cellular properties.