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Gold nanoparticles for modulating neuronal behavior

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journal contribution
posted on 2024-07-11, 09:17 authored by Chiara Paviolo, Paul StoddartPaul Stoddart
Understanding the detailed functioning and pathophysiology of the brain and the nervous system continues to challenge the scientific community, particularly in terms of scaling up techniques for monitoring and interfacing with complex 3D networks. Nanotechnology has the potential to support this scaling up, where the eventual goal would be to address individual nerve cells within functional units of both the central and peripheral nervous system. Gold nanoparticles provide a variety of physical and chemical properties that have attracted attention as a light-activated nanoscale neuronal interface. This review provides a critical overview of the photothermal and photomechanical properties of chemically functionalized gold nanoparticles that have been exploited to trigger a range of biological responses in neuronal tissues, including modulation of electrical activity and nerve regeneration. The prospects and challenges for further development are also discussed.

Funding

ARC | IC140100023

Industrial Transformation Training Centre in Biodevices and Diagnostics : Australian Research Council (ARC) | IC140100023

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PDF (Published version)

ISSN

2079-4991

Journal title

Nanomaterials

Volume

7

Issue

4

Article number

article no. 92

Pagination

92-

Publisher

MDPI AG

Copyright statement

Copyright © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Language

eng

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