We present an analysis of the pairwise velocity statistics from a suite of cosmological N-body simulations describing the 'Running Friedmann-Lemâitre-Robertson-Walker' (R-FLRW) cosmological model. This model is based on quantum field theory in a curved space-time and extends Λ cold dark matter (CDM) with a time-evolving vacuum energy density, ρΛ. To enforce local conservation of matter, a time-evolving gravitational coupling is also included. Our results constitute the first study of velocities in the R-FLRWcosmology, and we also compare with other dark energy simulations suites, repeating the same analysis. We find a strong degeneracy between the pairwise velocity and σ8 at z = 0 for almost all scenarios considered, which remains even when we look back to epochs as early as z=2.We also investigate various coupled dark energy models, some of which show minimal degeneracy, and reveal interesting deviations from ΛCDM that could be readily exploited by future cosmological observations to test and further constrain our understanding of dark energy.