We examine how to signify and quantify the mesoscopic quantum coherence of approximate two-mode NOON states and spin-squeezed two-mode Bose-Einstein condensates (BEC). We identify two criteria that verify a nonzero quantum coherence between states with quantum number different by n. These criteria negate certain mixtures of quantum states, thereby signifying a generalized n-scopic Schrodinger cat-type paradox. The first criterion is the correlation <(a) over cap (+n) (b) over cap (n) > not equal 0 (here (a) over cap and (b) over cap are the boson operators for each mode). The correlation manifests as interference fringes in n-particle detection probabilities and is also measurable via quadrature phase amplitude and spin-squeezing measurements. Measurement of <(a) over cap (+n) (b) over cap (n) > enables a quantification of the overall nth order quantum coherence, thus providing an avenue for high efficiency verification of high-fidelity photonic NOON states. The second criterion is based on a quantification of the measurable spin-squeezing parameter xi N. We apply the criteria to theoretical models of NOON states in lossy interferometers and double-well trapped BECs. By analyzing existing BEC experiments, we demonstrate generalized atomic "kitten" states and atomic quantum coherence with n sic 10 atoms.