A T-cell mediated clonal selection algorithm

The two-signal theory of lymphocyte activation was proposed more than thirty-five years ago and since that time has been elaborated and experimentally demonstrated to be a mediation process for the activation of both B and T lymphocytes. Modern names for the theory include associative recognition theory, the ARA model, and co-stimulation for Tcells. This work proposes the integration of T-cell mediation of activated B-lymphocytes into the elaborated clonal selection algorithm (ECSA). The resultant system provides a decoupled condition-action cognitive system that appears to have much similarity with classifier systems and may be an example of the reinforcement-learning paradigm.