A population-based clonal selection algorithm and extensions

Immune systems do not exist in isolation, rather the cellular and molecular interactions occur within the tissues of a host, and populations of hosts exist together in an environment. This work investigates the relationship between the acquired immune system and a pathogenic environment at the ‘hostpopulation’ scale. A minimal population-based clonal selection algorithm is proposed and extend to include the host-population immunological principles of inter-population pathogen dynamics, vaccination/inoculation, and transplanted acquired immune cells.