An Investigation of the Efficacy of Curcumin for the Prevention and Amelioration of Cognitive Decline in the Elderly

Epidemiological and pre-clinical studies suggest that curcumin may protect against or ameliorate, cognitive decline in both normal aging and dementia. Despite its therapeutic potential, there is a relative paucity of data regarding the cognitive effects of curcumin in humans. This thesis investigated the acute and chronic effects of oral curcumin administration on cognitive function, mood, and wellbeing, in older adults. A number of beneficial effects were observed including enhancements in learning, working memory and attention, consistent with improved hippocampal function. Curcumin was also associated with reduced fatigue and resistance to the detrimental effects of cognitive stress on mood.