Antimicrobial peptides based on puroindolines: investigations of their biocidal effect, potential for resistance development, and anticancer activity

Antimicrobial peptides (AMPs) derived from wheat proteins were investigated for their ability to combat drug-resistant pathogens and biofilms. These peptides showed activity against bacteria and fungi causing infections, disrupted biofilm formation, and exhibited potential anticancer effects. Resistance to the peptides was limited and transient, highlighting their therapeutic promise. The findings contribute to developing alternative treatments for multidrug-resistant infections and potential cancer therapies, addressing urgent global health challenges.