Colloidal crystal based plasma polymer patterning to control Pseudomonas aeruginosa attachment to surfaces

Infection caused by bacterial biofilm formation on most types of biomedical device and implant surfaces has become a major problem in health care and is a substantial risk to patient health and safety. To overcome this issue, in this thesis the role of surface topography, surface chemistry and biomolecule (DNA) immobilisation upon initial bacterial attachment on substrates was studied. Overall, the results demonstrated in the thesis are an ideal platform to study a range of different surface properties and their roles in bacterial attachment that will help understand the unknown mechanisms that occur at biointerfaces that lead to biofilm formation and medical implant centered infections.