Development of an Active Pharmaceutical Ingredient (API) Loaded Hydrogel Targeting Bacterial Vaginosis

The administration of therapeutic drugs includes various methods, with mucosal administration focusing on applying drugs through mucosal glands in areas like the mouth, nose, throat, rectum, and vagina. The vaginal route is a promising avenue for drug delivery, with carrier systems like vaginal tablets, hydrogels, and suppositories. This research evaluates hydrogels as carriers for active pharmaceutical ingredients (API) targeting bacterial vaginosis (BV), a common infection in women of reproductive age, posing risks to sexual and reproductive health. The thesis reviews recent studies on the vaginal microbiome, BV conditions, and various vaginal drug delivery systems. The goal is to enhance our understanding of effective drug delivery for treating BV, contributing to improved women's health.