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Engineering TGF-B proteins to restore tissue homeostasis

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posted on 2024-07-12, 18:47 authored by Katharine Elizabeth Johnson
The Transforming Growth Factor-beta (TGF-β) superfamily is a large family of proteins that are master regulators of tissue homeostasis. Their deregulated activities are associated with various human diseases. While numerous therapeutic agents have been developed for reducing supra-physiological levels of these proteins, progress toward therapeutics to restore protein levels has been less successful. This research demonstrates that by making targeted modifications to the amino acid sequences of selected TGF-β ligands, their half-lives, bioactivity, and activation status can be improved. Taken together, these approaches form a blueprint that will aid further research into TGF-β therapeutics.

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Thesis type

  • Thesis (PhD by publication)

Thesis note

Thesis by publication, submitted for the Degree of Doctor of Philosophy, Swinburne University of Technology, 2018.

Copyright statement

Copyright © 2018 Katharine E. Johnson.

Supervisors

Tony Barton

Language

eng

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