Exploring modifiable risk factors of cognitive ageing: Evidence from resting state fMRI

Increased population ageing and the associated global burden of age-associated cognitive impairments has led to a critical need for better understanding of modifiable ageing processes which impact brain function. The present thesis contributes to our understanding of the neural correlates of cognitive ageing, focusing on resting-state functional magnetic resonance imaging (rs-fMRI). Across nutrition and appetite signalling the work presented advances our understanding of the neural correlates of cognitive ageing and potentially modifiable central mechanisms of ageing. In the absence of any effective drug therapy for cognitive decline or dementia, this may lead to the identification of new treatment targets.