Fitness and Aortic Stiffness: Modifiable Predictors of Cognitive Ageing

Older age is accompanied by progressive decline in memory and thinking, often culminating in cognitive impairment and dementias such as Alzheimer's disease. With no pharmacological interventions available, research has shifted towards identifying and understanding potentially modifiable risk factors. This thesis revealed that both physical fitness and stiffness of the aorta are important interventional targets for slowing cognitive decline in older people. However, it was also found that a `one size fits all' approach to intervention strategies may not necessarily be ideal. These findings contribute towards international efforts to reduce the rates of cognitive impairment and dementia in our ever-ageing society.