Immobilisation strategies for the tethering of polymers and antimicrobial peptides to design multifunctional surface coatings

Unwanted accumulation of bacteria and protein on surfaces is considered a major problem in healthcare environments which can lead to infection and implant rejection. The research described in this Thesis outlines several approaches for the modification of surfaces to reduce protein adsorption and bacterial colonisation through the chemical immobilisation of non-fouling polymers and antimicrobial peptides. Development and incorperation of these functionalised surface coatings to medical devices and implants will greatly benefit society as they will reduce the risk of infection and other related sequelae including patient suffering, implant rejection and costs associated with avoidable treatments.