Magnetic Resonance Spectroscopy: Investigating Glutathione with Nutraceuticals to Reduce Oxidative Stress in the brain, and Improve Cognition for Healthy Ageing

Ageing is linked to a progressive loss of memory, cognitive decline and increased oxidative stress. Finding effective interventions to support brain health is therefore crucial. The neuroimaging technique magnetic resonance spectroscopy was used to examine whether the nutraceuticals Bacopa-monnieri and Pycnogenol could reduce oxidative stress and improve cognitive function in older adults by increasing brain levels of glutathione, an important antioxidant. Cognitive improvement was not observed in response to intervention. Glutathione significantly increased only after Pycnogenol supplementation. It is hoped that this research contributes to establishing effective interventions facilitating improved health outcomes and cognitive support for healthy ageing.