Mathematical models to understand the role of delay and noise in miR-17-92 regulatory network

This thesis seeks to investigate the intricate relationship between microRNAs (miR-17-92), proteins E2F and Myc, and their role in regulating cellular pathways. Recent studies in cancer biology have demonstrated the vital role of microRNAs in tumor development, either as oncogenes or tumor suppressor genes. Using mathematical modelling, this thesis endeavours to uncover the complexities of the non-linear systems between miR-17-92 and E2F/Myc, thereby elucidating the molecular basis of cancer and the role of microRNAs in disease. It is hoped that this in-depth examination will reveal new information about the interaction between these components.