Multi-Modal Characterisation of Deep Brain Stimulation in Obsessive-Compulsive Disorder: Clinical, Phenomenological and Advocacy Updates

Obsessive-compulsive disorder (OCD) is a complex and debilitating condition. This thesis explores deep brain stimulation (DBS), a neurostimulation therapy for OCD that targets pathological brain circuits, offering hope for people with treatment refractory OCD. Through eight publications, the thesis presents clinical, neuroimaging, psychosocial, self-report, and phenomenological outcomes, updates on the level of scientific evidence and clinical efficacy, and rationale for greater access to care. Also, a clinical guideline for managing patients and a cognitive model of recovery are proposed. The thesis represents a comprehensive multi-modal examination of DBS efficacy and mechanisms, and highlights the need for personalized and standardized care.