Multi-electrode array for high resolution impedance-based analysis of adherent cell cultures

The research project was directed towards the development of a microscale multi electrode array device as a tool that probes electrical properties (i.e. the impedance spectrum) of adherent single cells to identify their biological characteristics. The existing models of the cell impedance were refined to obtain a parametric model of the single cell adherent on a microelectrode. The simulations allowed to find corresponding biological markers from the impedance spectrum acquired by culturing mouse cells and human stem cells in the device. Direct applications range from fundamental research in cell biology, to applied medical diagnostics, to cell farms for cell therapies.