Multitarget-directed phytochemicals to combat plaques and tangles in Alzheimer's disease and improving its pharmacokinetics using nanoencapsulation

One of the major hurdles facing drug discovery for Alzheimer’s disease (AD) is its multifactorial nature involving several molecular targets that contribute to its etiopathology. Thus, a multitarget ligand was proposed in this study as a promising therapeutic strategy to address the complex nature of AD. The findings indicate that butein, a plant polyphenol, displayed drug-like properties and can modulate multiple targets of AD. In the context of pharmacology, the bioavailability of the compound is crucial for therapeutic implication; the outcomes from this study suggested that the reported polymer-lipid nanoencapsulation was efficient in improving stability, solubility and bioavailability of butein.