posted on 2024-07-13, 08:56authored bySanjida Halim Topa
Certain bacteria associated with humans use chemical communication mechanisms to switch on their pathogenic characteristics leading to chronic infections. Antibiotics function by killing pathogenic bacteria but bacteria frequently develop resistance. Dr Topa’s research used a component of cinnamon oil that interfered with the pathogen’s chemical communication mechanisms, thus precluding pathogenesis development. This approach limits the tendency for bacteria to develop resistance since the bacteria are not killed. The cinnamon oil component was fabricated into novel nanofibre materials, which demonstrated anti-pathogenesis action in a non-killing fashion. The projected practical outcomes include solutions to medical implant device and chronic wound infections.
History
Thesis type
Thesis (PhD)
Thesis note
The thesis is submitted for the degree of Doctor of Philosophy, Swinburne University of Technology, 2018.