Tailored Cold-spray Fabrication of Multifunctional Biomedical Device Surfaces

Medical device-associated infections present a persistent challenge, significantly contributing to postsurgical morbidity and mortality. This study explores innovative surface engineering techniques, including the cold spray method, to improve the antimicrobial efficacy of common polymeric biomaterials. Furthermore, the research demonstrate the development of multifunctional biomaterials with controlled interactions with living biological systems. These advancements exhibit enhancements in osteogenic activity, bacterial repellence, bactericidal effectiveness, and host compatibility of biomaterial surfaces through tailored manipulation of the physical and chemical properties. By addressing these critical factors, the study aims to offer a viable solution for reducing medical device-associated infections and ultimately improving patient outcomes.