The Role of TGF Beta Proteins In The Regulation of Skeletal Muscle Mass

Skeletal muscles are one of the most vital tissues of human body and excessive loss of skeletal muscle mass (also known as muscle wasting) can prove fatal to human body. TGF Beta proteins, activins and myostatin are established negative regulators of skeletal muscle mass. Myostatin is a natural antagonist of muscle growth, whereas increased serum activin levels are associated with muscle wasting in diseased conditions such as cancer. The primary focus of this research was to develop a bi-specific inhibitor of activin and myostatin as a potential therapeutic to treat muscle wasting in severe conditions of muscle wasting.