The cognitive and neurobiological mechanisms of thought disorder in schizophrenia

Schizophrenia is a mental illness with a substantial disease burden. However, the scientific study of schizophrenia has been limited by its heterogeneity. This research used a symptom-focused approach to investigate the cognitive and neuroimaging correlates of thought disorder, one domain of symptoms that are associated with schizophrenia. Measurements of thought disorder were considered from a first-person perspective, as well as from observations made from a third-person perspective. The work conducted emphasises the need to improve these measurements of thought disorder so that future research can establish the reasons for its occurrence and how it might be better treated.